Mouse models for peanut allergy
Peanut allergy is one of the most common food allergies. Currently 1-2% of the world population has peanut allergy. Amongst them are many children who suffer from this allergy and the prevalence in children in the US, Europe and Australia has been reported to have doubled over the past 10 years. In the majority of cases peanut allergy is a lifelong disease, making it is also very common amongst adults. Symptoms are often mild to moderate, but they can unfortunately be life-threatening as well. In highly sensitive patients, even the tiniest amount of peanut protein (sub-milligram) can trigger an allergic reaction. Oral exposure is the most common route for triggering adverse reactions, including the life-threatening ones, but inhalation and skin exposure can also induce symptoms. Central to the adverse reactions to peanut allergens are specific IgE antibodies that are bound to receptors on the surface of mast cells and basophils. Upon exposure to peanut protein, these receptors can be crosslinked, leading to mast cell/basophil degranulation. This can kick-off an individually varying spectrum of allergic symptoms including life-threatening anaphylaxis.
For research purposes we have developed a peanut extract. Click here to go straight to our peanut extract.
We have gathered several mouse models for peanut allergy:
1. CT-Peanut induced Anaphylaxis
2. SEB_Peanut induced Anaphylaxis
3. Adjuvant free Peanut induced sensitisation
4. CT_Peanut induced anaphylaxis in C3H/HeJ
5. Humanized Peanut induced anaphylaxis model
Click on the link below to see more details.