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Quotation

Induced asthma – Acute sensitization/ challenge model (17 days)

Model 3: Acute sensitization/ challenge model (17 days)

  • Description: Sensitized with HDM by intranasal administration on day 0, followed by intranasal challenge at days 14, 15, 16 and 17. Mice were sacrificed 3 hours after the last challenge.
  • Duration: 17 days.
  • Attributes: Acute sensitisation/ challenge model.
  • Endpoints: Total and differential cell count in the BALF/Lung.
  • Material used: D. pteronyssinus extract from Citeq

Mice sensitized and challenged with HDM have an neutrophilic and eosinophilic response in both Lung and BALF. Treatment with HDM induces T cell (CD4+ and CD8+) and B cell response in both Lung and BALF.